The Strength of Calcium
with the Purity of Genistein
Pay no more than $45 on every Fosteum prescription


Safety Profile

Estrogen Receptors

Certain cells in the body contain estrogen receptors. There are two types of these estrogen receptors, estrogen receptor alpha (ERɑ) and estrogen receptor beta (ERᵦ) and they trigger different actions when activated. Think of them as locks that open different doors when the key is used. ERɑ has been implicated in activating cancers of the breast and uterus, while ERᵦ has been shown to be active when bone mineralization is taking place. Thus, we want to activate ERᵦ, but we want to minimize the activation of ERɑ. Genistein does just that. As shown in the table below, estradiol (the hormone used in hormone replacement therapy) binds equally to both ERɑ and ERᵦ. That is why hormone replacement therapy protects bone but may trigger cancers of the breast or uterus. The replacement bone protector, Evista® (raloxifene), binds to ERɑ more than four times as much as to ERᵦ, thus, while it does show some effect in protecting bone in post-menopausal women, it can also trigger cancers. Genistein, however, binds very minimally to ERɑ, while binding strongly to ERᵦ. Therefore, genistein builds bone, but does not show any indication that it triggers cancers of the breast or uterus.

Avg. +3% per year Increase in BMD over 3 years
No adverse effect on endometrial thickness
Favorable cardiovascular safety profile

Estrogen Safety is Relative to Estrogen Receptor Affinity

Endometrial Thickness

Another measurement that indicates an increased chance of uterine cancer is thickening of the endometrium, the wall of the uterus. Studies over a three year period have shown that dosing with the genistein in Fosteum PLUS does not cause thickening. In fact, the measurements, showed that the endometrial thickness of the women taking the genistein in Fosteum PLUS was the same as those taking only calcium and vitamin D3, the placebo.

In multiple studies, looking at known risk factors for cancer and heart disease, like, cholesterol profiles, vasoconstriction/dilation, nitrous oxide production, endometrial thickness, estrogen receptor binding affinity, and more, all measurements were either not changed from placebo or and baseline, or were improved from placebo and baseline.

Cardio Risk

Recent studies have shown that excess consumption of calcium, over 1,400 mg/day, may increase the risk of cardiac problems, like heart attack. (References)

  1. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 341:c3691.
  2. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ 2010;342:d2040.
  3. Bolland MJ, Barber PA, Doughty RN, Mason B, Horne A, Ames R, et al. Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ 2008;336:262-6.
  4. Lewis JR, Calver J, Zhu K, Flicker L, Prince RL. Calcium supplementation and the risks of atherosclerotic vascular disease in older women: results of a 5-year RCT and a 4.5-year follow-up. J Bone Miner Res 2011;26:35-41.
  5. Iso H, Stampfer MJ, Manson JE, Rexrode K, Hennekens CH, Colditz GA, et al. Prospective study of calcium, potassium, and magnesium intake and risk of stroke in women. Stroke 1999;30:1772-9.
  6. Umesawa M, Iso H, Date C, Yamamoto A, Toyoshima H, Watanabe Y, et al. Dietary intake of calcium in relation to mortality from cardiovascular disease: the JACC Study. Stroke 2006;37:20-6.
  7. Umesawa M, Iso H, Ishihara J, Saito I, Kokubo Y, Inoue M, et al. Dietary calcium intake and risks of stroke, its subtypes, and coronary heart disease in Japanese: the JPHC Study Cohort I. Stroke 2008;39:2449-56.
  8. Bostick RM, Kushi LH, Wu Y, Meyer KA, Sellers TA, Folsom AR. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 1999;149:151-61.
  9. Larsson SC, Virtamo J, Wolk A. Potassium, calcium, and magnesium intakes and risk of stroke in women. Am J Epidemiol 2011;174:35-43.
  10. For this reason, you should not take large quantities of calcium, but rather you should stick to the recommended daily intake (RDI) of 1,000 mg/day or 1,200 mg/day depending on your age. The total recommended intake of calcium of 1,000 mg/d for those under 70 and 1,200 mg/d for those over 70 is from all sources, your diet plus any calcium in supplements and multivitamins or medical foods such as Fosteum PLUS. The average American woman takes in between 748 mg (over 70) and 864 mg (under 50) of calcium from diet alone. (Reference: Mangano KM, Walsh SJ, Insogna KL, Kenny AM, Kerstetter JE. Calcium intake in the United States from dietary and supplemental sources across adult age groups: new estimates from the National Health and Nutrition Examination Survey 2003-2006. J Am Diet Assoc 2011;111:687-95.)

This is the reason that Fosteum PLUS contains 174 mg of additional elemental calcium; it is enough to take the diet of an average women over 40 to the recommended intake without providing so much as to possibly threaten your her heart. Today, no woman should be eating a healthy diet, taking Fosteum PLUS and taking two 500 mg calcium supplements, unless there is a specific medical needreason for her doing so.

  • Why Fosteum Plus?
  • Why Medical Foods?
Why Fosteum Plus?
Fosteum PLUS is the only product available clinically proven to manage bone loss that offers calcium, phosphate and MK-7 in a single capsule along with genistein, citrated zinc bisglycinate and vitamin. Each ingredient is chosen for its specific action in helping to build quality bone.
Why Medical Foods?
Medical foods are an official Food and Drug Administration (FDA) category of products that must have therapeutic value based on recognized science. The name “medical foods” was chosen by the U.S. Congress. All medical foods must meet the distinctive dietary requirements of a particular disease.