The Strength of Calcium
with the Purity of Genistein
Pay no more than $45 on every Fosteum prescription

Healthcare Professionals

Frequently Asked Questions by Healthcare Professionals

  1. What are the most common side effects of Fosteum PLUS?
  2. How should my patients take Fosteum PLUS?
  3. Fosteum PLUS contains a phytoestrogen. Does it have any adverse effects on breast or reproductive tissues?
  4. Does Fosteum PLUS have any hepatic or renal effects?
  5. Have the effects of genistein on cardiovascular function been investigated?
  6. Can I obtain Fosteum PLUS samples for my practice?
  7. Does Fosteum PLUS have any effect on menopausal symptoms?
  8. What is the managed care status of Fosteum PLUS?
  9. What is a medical food?

What are the most common side effects of Fosteum PLUS?

The most common side effects of Fosteum PLUS are mild to moderate GI symptoms, like nausea, dyspepsia and constipation. If a patient has these symptoms, they may be alleviated by taking Fosteum PLUS with food.

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How should my patients take Fosteum PLUS?

Fosteum PLUS should be taken twice a day, There is calcium and vitamin D3 in Fosteum PLUS, but additional calcium and/or vitamin D3 supplementation may be recommended to ensure adequate intake of these crucial nutrients if the patient’s diet is inadequate. . Fosteum PLUS has no postural limitations and may be taken with or without food and with any beverage. This convenient regimen will likely lead to high levels of compliance among your patients, and may serve as a reminder to take other medications and/or supplements.

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Fosteum PLUS contains a phytoestrogen. Does it have any adverse effects on breast or reproductive tissues?

In clinical trials possible estrogenic effects of genistein were actively investigated. Clinical trials included the following safety endpoints:

  1. Digital mammograms;
  2. Uterine ultrasounds;
  3. Endometrial biopsies in patients with endometrial thickness >8 mm or vaginal bleeding;
  4. Vaginal cytology.

Importantly, there were no differences found between the genistein and the placebo groups, nor changes from baseline over periods as long as three years in these measurements. These data suggest that Fosteum PLUS does not produce estrogenic effects on breast or reproductive tissues. This is supported by in vitro studies showing that the genistein in Fosteum PLUS binds strongly to ERᵦ, the receptor responsible for bone, but minimally to ERɑ, the receptor implicated in breast and uterine cancer.

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Does Fosteum PLUS have any hepatic or renal effects?

In clinical trials, there were no changes in laboratory markers of kidney or liver function among healthy postmenopausal women over a three year period.

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Have the effects of genistein on cardiovascular function been investigated?

The genistein in Fosteum PLUS was shown to increase plasma nitric oxide breakdown products, reduce endothelin-1 levels and improve endothelial-dependent vasodilation in postmenopausal women. In a two year study of 389 postmenopausal women, administration of the genistein in Fosteum PLUS was shown to significantly reduce plasma levels of the cardiovascular risk markers fibrinogen, F2-isoprostanes, sICAM-1 and sVCAM-1 after 24 months compared to placebo. Other markers of CV safety such as cholesterol, homocysteine and CRP were unchanged. Therefore, based on results from laboratory tests of cardiovascular risk, Fosteum PLUS appears safe for the heart and vasculature.

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Can I obtain Fosteum PLUS samples for my practice?

You can fill in the Request Samples form on this website or you can call 480-483-1410 to have a sample request form faxed to you.

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Does Fosteum PLUS have any effect on menopausal symptoms?

In a 12-month, prospective, randomized, double-blind, placebo-controlled study involving 247 symptomatic (five or more hot flashes per day at baseline), post-menopausal women, the genistein in Fosteum PLUS was shown to reduce the average number of hot flashes in 74% of the women by approximately 50%. The severity of hot flashes was also reduced by 37.5% over the 12 month period. A significant reduction in hot flash number and severity was observed at the 1, 3, 6, and 12 month follow-up visits, with progressive improvement observed throughout the treatment period. Anecdotally, some women have reported reductions in vasomotor symptoms within the first week of taking Fosteum PLUS.

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What is the managed care status of Fosteum PLUS?

Fosteum PLUS is covered by many managed care organizations, but coverage varies by plan. Even in cases in which Fosteum PLUS is not covered by a patient's plan, the price of Fosteum PLUS falls within the standard range of third tier co-pays and is approximately 40% less expensive than drug treatments for bone loss. Primus also offers a point-of-sale discount card that a patient may use for savings on Fosteum PLUS and many other prescription products. These cards can be requested on-line.

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What is a medical food?

Medical foods are a special category, established by federal law and regulated by the FDA. Medical foods are designed for the dietary management of a specific disease state and must meet a specific series of requirements including:

  • GRAS (Generally Recognized As Safe) status for all ingredients - this rigorous safety standard applies to all food ingredients;
  • The nutrients in medical foods must meet the distinctive requirements of a specific disease state;
  • Medical foods must be administered orally;
  • Medical foods must be administered under a physician's supervision (Rx required);
  • The nutrients provided must not be available by a simple change of diet.

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  • Why Fosteum Plus?
  • Why Medical Foods?
Why Fosteum Plus?
Fosteum PLUS is the only product available clinically proven to manage bone loss that offers calcium, phosphate and MK-7 in a single capsule along with genistein, citrated zinc bisglycinate and vitamin. Each ingredient is chosen for its specific action in helping to build quality bone.
Why Medical Foods?
Medical foods are an official Food and Drug Administration (FDA) category of products that must have therapeutic value based on recognized science. The name “medical foods” was chosen by the U.S. Congress. All medical foods must meet the distinctive dietary requirements of a particular disease.